A promising treatment for trisomy 21

DECRYPTION – The injection of a hormone has improved the cognitive abilities of a small number of patients.

For people with Down syndrome, the issue of empowerment in adulthood is key. This disease, characterized by the presence of a third chromosome 21, whole or partial, induces, among other things, an intellectual deficiency of varying degrees. However, French and Swiss researchers have obtained interesting results by administering hormone treatment to adults with Down syndrome for six months. The molecule used is GnRH, a hormone naturally produced by the hypothalamus in the brain to regulate reproduction and puberty. Why the researchers, whose work is published this Thursday in Science, did they pay attention to him in trisomy 21? On the one hand, previous studies have shown that neurons sensitive to this hormone have an action in regions of the brain controlling cognition – the reason why the same molecule is also beginning to be tested in Alzheimer’s disease.

In addition, the team of Vincent Prévot, from…

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